Sprinting toward the sidelines on a post route, Holmes made an impressive catch, but fell awkwardly on his left wrist. He immediately could tell there was something wrong, showing discomfort as he removed his helmet and walked toward the sidelines.
"It's pretty serious," Hazell said to the media after Wednesday's practice. "He's getting an MRI right now, so we'll find out for sure when we get the MRI, but it's pretty serious."
Holmes, a 6-foot-5, 243-pound tight end from Miramar, Florida, leads Purdue in receptions with a total of nine.
Much of Purdue's pro-style offense relies on strong play from the tight end position. Now, the Boilermakers must adjust.
"It puts a lot of strain on your two-tight end sets, so we'll have to do some other things," Hazell said.
Junior Justin Sinz is the next man up for Purdue at tight end, but Hazell said seniors Patrick Bade and Sterling Carter will be counted on, too. 6-foot-7 redshirt freshman Carlos Carvajal could also provide a big target in the Boilermaker offense.
"They've got to do a good job and step up," Hazell said.
Purdue hosts No. 21 Notre Dame on Saturday night. In facing a stifling defense, the Boilermakers will need to find a new way to create mismatches.